6533b85dfe1ef96bd12bdf1e

RESEARCH PRODUCT

Enhanced In Situ Availability of Aphanizomenon Flos-Aquae Constituents Entrapped in Buccal Films for the Treatment of Oxidative Stress-Related Oral Diseases: Biomechanical Characterization and In Vitro/Ex Vivo Evaluation

Gioacchino AlottaEmanuela BolognaMassimiliano ZingalesGiuseppina CampisiViviana De CaroFrancesco SeiditaDenise Murgia

subject

Antioxidantbuccal filmmedicine.medical_treatment<i>Aphanizomenon flos-aquae</i>lcsh:RS1-441Pharmaceutical Science02 engineering and technologymedicine.disease_causeArticlelcsh:Pharmacy and materia medica03 medical and health sciences0302 clinical medicineparasitic diseasesOS-related oral diseasesmedicineFood scienceEudragit E100Chemistryex vivo permeationBuccal administrationPenetration (firestop)Aphanizomenon flos-aquaePermeation021001 nanoscience & nanotechnologyBioavailabilitySettore CHIM/09 - Farmaceutico Tecnologico Applicativo030220 oncology & carcinogenesishigh frequency homogenizationOS-related oral diseasebiomechanical testSwellingmedicine.symptom0210 nano-technologyEx vivoOxidative stress

description

In recent years, the key role of oxidative stress in pathogenesis of oral diseases has been emphasized and the use of antioxidant agents has been encouraged. Aphanizomenon flos-aquae (AFA) is a unicellular blue-green alga with antioxidant and anti-inflammatory properties. The aim of this study was the formulation and characterization of mucoadhesive thin layer films loaded with AFA, finalized to the treatment of oxidative stress (OS)-related oral diseases. First, to enhance the bioavailability of AFA constituents, the raw food grade material was appropriately treated by a high frequency homogenization able to disrupt cell walls. Thus, Eudragit&reg

yearjournalcountryeditionlanguage
2019-01-17Pharmaceutics
https://doi.org/10.3390/pharmaceutics11010035