6533b85dfe1ef96bd12bdf4c
RESEARCH PRODUCT
Subviral Dense Bodies of Human Cytomegalovirus Stimulate Maturation and Activation of Monocyte-Derived Immature Dendritic Cells
Sebastian KlobuchBodo PlachterCaroline SauerSimone ThomasWolfgang Herrsubject
Human cytomegalovirusMacromolecular SubstancesCellular differentiationmedicine.medical_treatmentImmunologyAntigen presentationCongenital cytomegalovirus infectionCytomegalovirusBiologyImmune controlMicrobiologyAntiviral immunityVirologymedicineHumansAntigen PresentationMonocyte derivedCell DifferentiationDendritic Cellsbiochemical phenomena metabolism and nutritionmedicine.diseaseCell biologyCytokineInsect ScienceImmunologyPathogenesis and ImmunityCytokinesdescription
ABSTRACT Dendritic cells play a central role in the immune control of human cytomegalovirus (HCMV) infection. This work aimed at investigating the impact of noninfectious, subviral dense bodies of HCMV on the maturation and activation of dendritic cells (DC). Treatment of immature DC with dense bodies led to the maturation of these cells and significantly increased their capacity for cytokine release and antigen presentation. Dense body-activated DC may thereby contribute to the development of antiviral immunity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-10-15 | Journal of Virology |