6533b85dfe1ef96bd12be03a
RESEARCH PRODUCT
Efficient synthesis of quaternary and P-stereogenic phosphonium triflates
Emmanuelle RémondArnaud TessierSylvain JugéJerome BayardonFrédéric R. Lerouxsubject
General methodMolecular StructureTrimethylsilyl[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistryArylOrganic ChemistryStereoisomerism010402 general chemistry01 natural sciencesBiochemistryAryne0104 chemical sciencesStereocenterchemistry.chemical_compoundOrganophosphorus Compoundschemistry[ CHIM.ORGA ] Chemical Sciences/Organic chemistryOrganic chemistryPhosphoniumPhysical and Theoretical ChemistryComputingMilieux_MISCELLANEOUSdescription
An efficient and general method for the preparation of achiral and chiral phosphonium salts is reported. This synthesis is based on the quaternization of phosphines and their derivatives with arynes generated in situ from 2-(trimethylsilyl)aryl triflates. This methodology is successfully applied to the synthesis of new valuable P-stereogenic phosphonium triflates.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |