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RESEARCH PRODUCT
Opposite Role of Pro-Inflammatory Alleles in Acute Myocardial Infarction and Longevity: Results of Studies Performed in a Sicilian Population
Giuseppe PaolissoBalistrericarmela RitaCalogero CarusoEnrico HoffmannGiuseppina Colonna-romanoMarco CarusoDomenico LioSonya VastoMaria Paola GrimaldiFlorinda ListìGregorio CaimiClaudio FranceschiCandoregiuseppinasubject
Receptors CCR5media_common.quotation_subjectPopulationMyocardial InfarctionDiseasePyrin domainGeneral Biochemistry Genetics and Molecular BiologyProinflammatory cytokineAMIlongevityHistory and Philosophy of SciencepyrinGenotypeHumansMedicineGenetic Predisposition to DiseaseAlleleeducationSicilyAllelesmedia_commonAged 80 and overeducation.field_of_studybusiness.industryGeneral NeuroscienceLongevityCytoskeletal ProteinsinflammationAcute DiseaseImmunologyCentenarianbusinessCCR5description
The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 | Annals of the New York Academy of Sciences |