6533b85dfe1ef96bd12be5f4
RESEARCH PRODUCT
’-omics’ technology and human reproduction: reproductomics
José A. HorcajadasFrancisco J. EstebanSandra MosqueraMaría MundiJosé Bellversubject
High ratemedicine.medical_specialtyPregnancyanimal structuresReproductive medicineObstetrics and GynecologyEmbryoBiologyOmicsBioinformaticsmedicine.diseaseTranscriptomeHuman reproductionMetabolomic profilingReproductive Medicineembryonic structuresMaternity and MidwiferyPediatrics Perinatology and Child Healthmedicinedescription
The success of assisted reproduction technology is highly dependent on a precise selection of gametes and embryos and determining the best endometrial window for embryo implantation. For many years, morphological criteria have constituted the only way to assess spermatozoon, oocytes, embryos and endometrial samples in order to improve outcomes. However, this approach has reached a ceiling of success and has been related to unacceptably high rates of multiple pregnancies. New technologies have been developed in order to improve the results and reduce risks via better selection of those gametes and embryos with the highest pregnancy potential, and of more favorable endometrial environments for embryo implantation. In addition, these technologies should ideally be objective, accurate, fast and affordable. Lately, the global strategies that are being employed in reproductive medicine include genomic, transcriptomic, proteomic, metabolomic profiling of oocytes, cummulus cells, granulosa cells, embryos, endomet...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-09-01 | Expert Review of Obstetrics & Gynecology |