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RESEARCH PRODUCT
Mechanism of the Antiretroviral Effect of dsRNA
W. E. G. MüllerHeinz-christoph SchröderH. Ushijimasubject
chemistry.chemical_classificationbiologyRNase PvirusesfungiRNAVirologychemistry.chemical_compoundRNA silencingImmune systemEnzymeBiosynthesischemistryInterferonmedicinebiology.proteinRibonuclease Lmedicine.drugdescription
The development of AIDS seems to be linked to an impairment of processes which are induced or activated by double-stranded RNA (dsRNA), such as the biosynthesis of interferon (IFN), production of 2′,5′-oligoadenylate (2-5A), ribonuclease L (RNase L) activity and different cell-mediated immune functions. A restriction of available bioactive dsRNA (or of dsRNA-dependent enzymes) may play an important role in the disease progression. The results summarized in this review show that defects in dsRNA-dependent pathways exhibited by AIDS patients can be reversed, at least in part, by exogenously supplied dsRNA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 |