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RESEARCH PRODUCT
Glaucasides A-C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire
Hichem Ben JannetMarie Aleth Lacaille-duboisAymen JabraneAymen JabraneOlivier DuchampJean François MirjoletFethia Harzallah-skhiriChiaki TanakaTomofumi Miyamotosubject
Human colon cancerAtriplexbiologyAtriplex parvifoliaChemistryStereochemistryAtriplex glaucaGeneral Materials ScienceGeneral ChemistryNuclear magnetic resonance spectroscopybiology.organism_classificationTwo-dimensional nuclear magnetic resonance spectroscopydescription
From the roots of Atriplex glauca L. var. ifiniensis (Caball) Maire (syn. of Atriplex parvifolia Lowe var. genuina Maire), three new saikosaponins designated as glaucasides A-C (1-3) were isolated together with the known 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl-saikogenin F (4). The structures of the new compounds were elucidated by extensive analysis of one-dimensional and two-dimensional NMR spectroscopy, FABMS, HR-ESIMS and chemical evidence as 13β,28-epoxy-16β,21β-dihydroxyolean-11-en-3β-yl O-β-D-[2-O-sulfate]-glucopyranosyl-(1 → 2)-α-L-arabinopyranoside (1), 13β,28-epoxy-16β,21β-dihydroxyolean-11-en-3β-yl O-β-D-[2-O-sulfate]-glucopyranosyl-(1 → 2)-α-L-arabinopyranosyl 21-O-{4-(secbutylamido)-butanoyl ester} (2) and 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl saikogenin G (3). The cytotoxic activities of these compounds were evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-01-03 | Magnetic Resonance in Chemistry |