6533b85dfe1ef96bd12be8a6
RESEARCH PRODUCT
From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?
Giulia PulianiAndrea LaniaFabio Lo CalzoValentina GuarnottaGiuseppe FanciulliAlessandra DicitoreCarmen RainoneAnnamaria ColaoGenoveffa PizzaManila RubinoGiovanni VitaleSevero CampioneFrancesco FerraùMaria Chiara ZatelliMary Anna VenneriEmilia SbardellaDiego FeroneMarco GalloRiccardo PofiRoberta ModicaLuigi BarreaErika GrossrubatscherFederica GrilloAntongiulio FaggianoFranz SestiRosa Maria RuggieriBarbara AltieriErika MessinaLuca PesP. RazzoreNikeAndrea M. IsidoriSergio Di MolfettaPasquale MalandrinoAndrea LenziManuela AlbertelliTiziana FeolaLaura RizzaGiovanna MuscogiuriFederica De CiccoFilomena BottiglieriElia GuadagnoElisa Giannettasubject
Endocrinology Diabetes and MetabolismTumor microenvironment.BiologyGut floraNeuroendocrine tumorsmedicine.disease_causedigestive systemArticle03 medical and health sciences0302 clinical medicineEndocrinologyImmune systemNeuroendocrine tumorGastro-medicineHumansCytokine030304 developmental biologyGastrointestinal NeoplasmsInflammation0303 health sciencesTumor microenvironmentMicrobiotadigestive oral and skin physiologymedicine.diseasebiology.organism_classificationCytokines; Inflammation; Microbiota; Neuroendocrine tumors; Tumor microenvironmentGastrointestinal MicrobiomeTumor microenvironment030220 oncology & carcinogenesisImmunologyDysbiosisCytokinesNeuroendocrine tumorsCarcinogenesisDysbiosisDrug metabolismdescription
AbstractGut microbiota is represented by different microorganisms that colonize the intestinal tract, mostly the large intestine, such as bacteria, fungi, archaea and viruses. The gut microbial balance has a key role in several functions. It modulates the host’s metabolism, maintains the gut barrier integrity, participates in the xenobiotics and drug metabolism, and acts as protection against gastro-intestinal pathogens through the host’s immune system modulation. The impaired gut microbiota, called dysbiosis, may be the result of an imbalance in this equilibrium and is linked with different diseases, including cancer. While most of the studies have focused on the association between microbiota and gastrointestinal adenocarcinomas, very little is known about gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs). In this review, we provide an overview concerning the complex interplay between gut microbiota and GEP NENs, focusing on the potential role in tumorigenesis and progression in these tumors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-15 |