6533b85dfe1ef96bd12be8ea
RESEARCH PRODUCT
Tuneable Transient Thermogels Mediated by a pH- and Redox-Regulated Supramolecular Polymerization.
Pol BeseniusDaniel SpitzerMarkus MezgerLeona Lucas RodriguesDavid Straßburgersubject
chemistry.chemical_classificationMethioninebiologyStereochemistrytechnology industry and agricultureSupramolecular chemistrymacromolecular substances02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesRedoxCatalysis0104 chemical sciencesSupramolecular polymerschemistry.chemical_compoundMonomerPolymerizationchemistrySelf-healing hydrogelsbiology.proteinBiophysicsGlucose oxidase0210 nano-technologydescription
A multistimuli-responsive transient supramolecular polymerization of β-sheet-encoded dendritic peptide monomers in water is presented. The amphiphiles, which contain glutamic acid and methionine, undergo a glucose oxidase catalyzed, glucose-fueled transient hydrogelation in response to an interplay of pH and oxidation stimuli, promoted by the production of reactive oxygen species (ROS). Adjusting the enzyme and glucose concentration allows tuning of the assembly and the disassembly rates of the supramolecular polymers, which dictate the stiffness and transient stability of the hydrogels. The incorporation of triethylene glycol chains introduces thermoresponsive properties to the materials. We further show that repair enzymes are able to reverse the oxidative damage in the methionine-based thioether side chains. Since ROS play an important role in signal transduction cascades, our strategy offers great potential for applications of these dynamic biomaterials in redox microenvironments.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-03 | Angewandte Chemie (International ed. in English) |