A Short Synthesis of Polysubstituted Pyrrolidines via α-(Alkylideneamino)nitriles

6533b85dfe1ef96bd12be951

RESEARCH PRODUCT

A Short Synthesis of Polysubstituted Pyrrolidines via α-(Alkylideneamino)nitriles

subject

Turn (biochemistry)Deprotonation Reaction sequence Chemistry Yield (chemistry)Organic Chemistry Organic chemistry Amino nitriles General Medicine Conjugated system Medicinal chemistry Pyrrole derivatives

description

α-(Alkylideneamino)nitriles can be deprotonated under mild conditions. Their conjugated anions react with enones in a 1,4-addition to yield δ-keto-α-(alkylideneamino)nitriles which in turn can be reduced to form pyrrolidines in a one-pot reaction sequence.

year	journal	country	edition	language
2004-08-17	Synlett

https://doi.org/10.1055/s-2004-817774

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6533b85dfe1ef96bd12be951

RESEARCH PRODUCT

A Short Synthesis of Polysubstituted Pyrrolidines via α-(Alkylidene­amino)nitriles

subject

description

A Short Synthesis of Polysubstituted Pyrrolidines via α-(Alkylideneamino)nitriles