6533b85dfe1ef96bd12be984
RESEARCH PRODUCT
Tumor necrosis factor alpha polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population.
Gianluigi ForloniSergio FogliarinoRosa Maria RuggieriMauro TettamantiUgo LuccaPierluigi QuadriFederico PiccoliLiana Terrenisubject
Apolipoprotein EMalePathologymedicine.medical_specialtyGenotypemedicine.medical_treatmentCentral nervous system diseaseDegenerative diseaseAlzheimer DiseaseRisk FactorsmedicineDementiaHumansVascular dementiaAgedAged 80 and overPolymorphism Geneticbusiness.industryTumor Necrosis Factor-alphaGeneral Neurosciencemedicine.diseaseCytokineItalyImmunologyTumor necrosis factor alphaDementiaFemaleAlzheimer's diseasebusinessdescription
A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) alpha as a genetic risk factor for VD and, associated with apolipoprotein E epsilon 4, for AD. We have assessed the association between TNF-alpha polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-alpha polymorphism on dementia has not been confirmed in this segment of the Italian population.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-06-01 | Neuroscience letters |