Talin1 sets the stage for dendritic cell activation

6533b85dfe1ef96bd12be998

RESEARCH PRODUCT

Talin1 sets the stage for dendritic cell activation

subject

Talin Cellular differentiation Immunology Integrin Insights Mice Conditional gene knockout Immune Tolerance Immunology and Allergy Animals Skin Mice Knockout Membrane Glycoproteins biology Chemistry Chemotaxis Toll-Like Receptors NF-kappa B Receptors Interleukin-1 Dendritic cell Cell biology Phosphotransferases (Alcohol Group Acceptor)Langerhans Cells Myeloid Differentiation Factor 88 biology.protein Cytokines Signal transduction Signal Transduction

description

In dendritic cells, talin1 links integrin binding to efficient TLR downstream signaling through interaction with MyD88 and PIP5K.

year	journal	country	edition	language
2020-07-01	The Journal of Experimental Medicine

10.1084/jem.20200574 http://europepmc.org/articles/PMC7398172

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