6533b85dfe1ef96bd12bf0e1
RESEARCH PRODUCT
Additional file 1: of KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome
Anna SandersErik De VriezeAnas AlazamiFatema AlzahraniErik MalarkeyNasrin SoruschLars TebbeStefanie KuhnsTeunis Van DamAmal AlhashemBrahim TabarkiQianhao LuNils LambacherJulie KennedyRachel BowieLisette HetterschijtSylvia Van BeersumJeroen Van ReeuwijkKarsten BoldtHannie KremerRobert KestersonDorota MoniesMohamed AbouelhodaRonald RoepmanMartijn HuynenMarius UeffingRob RussellUwe WolfrumBradley YoderErwin Van WijkFowzan AlkurayaOliver Blacquesubject
14. Life underwaterdescription
The phylogenetic distribution and sequence conservation of KIAA0556 orthologs in eukaryotes. Presence and sequence conservation of KIAA0556 are projected on the eukaryotic species tree to visualise the phylogenetic distribution of KIAA0556 orthologues as well as the distribution of the triple-repeat and quadruple-repeat configurations of the DUF4457 domains of unknown function. The black circles and white circles indicate which eukaryotic species contain or lack cilia/flagella. Recent KIAA0556 duplicates in Branchiostoma floridae and Paramecium tetraurelia are denoted by x2. *Dictyostelium discoideum protein sequence contains many â Nâ s (uncalled bases) in the N-terminal part of the sequence, indicative of sequencing errors. As a result we are unable to identify whether this region is indeed homologous to the human KIAA0556 N-terminus. Boxed schematic at bottom shows examples of C. elegans and human KIAA0556 with three and four repeat domains, respectively. (PDF 283 kb)
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |