6533b85dfe1ef96bd12bf2de

RESEARCH PRODUCT

Vinblastine-induced autophagocytosis: effects on liver glycogen

Pirrko Hirsimäki

subject

Blood GlucoseMaleendocrine systemmedicine.medical_specialtyPhosphorylasesAutophagocytosismedicine.medical_treatmentIntraperitoneal injectionBiophysicsBiologyVinblastineBiochemistryGlucagonMicechemistry.chemical_compoundPhagocytosisStructural BiologycAMPInternal medicineAutophagyCyclic AMPGeneticsmedicineAnimalsMolecular BiologyGlycogendigestive oral and skin physiologyVinoblastineCell BiologyVinblastineMicroscopy ElectronEndocrinologyLiverchemistryGlycogenhormones hormone substitutes and hormone antagonistsmedicine.drug

description

The possible similarities of the mechanism by which vinblastine induces autophagocytosis in liver were compared with the known effects of glucagon in glucagon-induced autophagocytosis. A single intraperitoneal injection of vinblastine produced a wave of autophagocytosis in less than 0.5 h in mouse hepatocytes. Liver glycogen content decreases simultaneously and blood glucose first increased and then decreased below control values. Both liver cAMP concentration and the activity of glycogen phosphorylase remained unchanged. These findings provide evidence that the induction of autophagocytosis after vinblastine injection is not mediated by cAMP. The increased degradation of glycogen may occur in the lysosomal system by means of increased autophagocytosis.

yearjournalcountryeditionlanguage
1983-01-10FEBS Letters
https://doi.org/10.1016/0014-5793(83)80349-4