Platelet Activation: a New Biological Activity of Guinea-pig C3a Anaphylatoxin

6533b85efe1ef96bd12bf364

RESEARCH PRODUCT

Platelet Activation: a New Biological Activity of Guinea-pig C3a Anaphylatoxin

Dieter Bitter-suermann Stefan Meuer Ulrich Hadding S. Becker

subject

Blood Platelets Anaphylatoxins Serotonin Time Factors Guinea Pigs Immunology chemical and pharmacologic phenomena Tritium Guinea pig Complement Inactivator Proteins Animals Platelet Anaphylatoxin Inducer Platelet activation Complement Inactivator Proteins biology Chemistry Temperature Biological activity Complement C3 General Medicine Chromium Radioisotopes Biochemistry biology.protein Antibody Peptides

description

3H-serotonin-release from labelled gp-platelets is established as a sensitive method for testing a new biological activity of gp-C3a anaphylatoxin in an autologous situation. Time-, dose- and temperature-dependent release reactions as well as specific inhibition by carboxypeptidase B and anti-C3a antibodies show that C3a is a potent and specific inducer of platelet activation. Inactive C3a does not induce 3H-serotonin-release but specifically inhibits the action of C3a on platelets.

year	journal	country	edition	language
1978-02-01	Scandinavian Journal of Immunology

https://doi.org/10.1111/j.1365-3083.1978.tb00441.x

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