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RESEARCH PRODUCT
Do not stress, just differentiate: role of stress proteins in hematopoiesis
Carmen GarridoGaëtan JegoThibault RattierC Boudescosubject
Cancer Researchmedicine.medical_specialtyCellular differentiationImmunologyBiologyMiceCellular and Molecular NeuroscienceHeat Shock Transcription FactorsInternal medicineHeat shock proteinmedicineAnimalsProtein IsoformsRNA MessengerHeat shockTranscription factorHeat-Shock ProteinsHematologyCell DifferentiationNews and CommentaryCell BiologyHematopoiesisCell biologyDNA-Binding ProteinsHeat shock factorHaematopoiesisCaspasesHSP60Heat-Shock ResponseTranscription Factorsdescription
Hematopoiesis permits the constant regeneration of the blood system and is a permanent example of cell differentiation. Defects in its tight regulation can lead to either cell death or abnormal proliferation and may translate into multiple types of blood disorders, including leukemia. Heat shock proteins (HSPs), the expression of which is controlled by heat shock factors (HSFs, currently four known members),1 are a set of highly conserved proteins induced in response to a wide variety of physiological and environmental stress. HSP/HSF overexpression or mislocalization has been described in many cancers, particularly in hematology, and other diseases. Therefore, the involvement of HSFs/HSPs in the differentiation of cells from a hematopoietic origin is critical and is at the center of many investigations.2, 3 Here, we present newly identified mechanisms used by HSFs and HSPs to control the differentiation of several types of hematopoietic-derived cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-29 | Cell Death & Disease |