6533b85efe1ef96bd12bfa7f
RESEARCH PRODUCT
Nutritional epigenomic and DNA-damage modulation effect of natural stilbenoids
Sara VolpesIlenia CruciataFederica CerauloChiara SchimmentiFlores NaselliCecilia PinnaMaurizio MauroPasquale PiconeSabrina DallavalleDomenico NuzzoAndrea PintoFabio Caradonnasubject
Settore BIO/18 - Geneticastilbenoids nutrigenomics resveratrol pterostilbene (±)-trans-δ-viniferin (±)-trans-pterostilbene dehydrodimer Caco-2 cells HepG-2 cells DNA methylation.Settore CHIM/10 - Chimica degli Alimentidescription
The aim of the present work is the evaluation of biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. In the present study, resveratrol, pterostilbene and for the first time their dimers (±)-trans-δ-viniferin, (±)-trans-pterostilbene dehydrodimer were evaluated in Caco-2 and HepG-2 cell lines as potential epigenetic modulators. Stilbenoids were added in a Caco-2 cell culture as a model of the intestinal epithelial barrier and in the HepG-2 as a model of hepatic environment, to verify their dose-dependent toxicity, ability to interact with DNA, and epigenomic action. Resveratrol, pterostilbene, and (±)-trans-pterostilbene dehydrodimer were found to have no toxic effects at tested concentration and were effective in reversing arsenic damage in Caco-2 cell lines. (±)-trans-δ-viniferin showed epigenomic activity, but further studies are needed to clarify its mode of action.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2023-01-12 |