6533b85efe1ef96bd12bfb60
RESEARCH PRODUCT
Angiogenesis control in spine regeneration
R.e. UngerEva DohleCharles James KirkpatrickRoman TsarykM. Santinsubject
musculoskeletal diseasesAngiogenesisRegeneration (biology)VEGF receptorsIntervertebral discAnatomyDegeneration (medical)Biologymusculoskeletal systemBone tissue engineeringmedicine.anatomical_structureTissue engineeringotorhinolaryngologic diseasesmedicinebiology.proteinsense organsBlood vesseldescription
Abstract: The intervertebral disc (IVD) has a complex vascularisation pattern. While the nucleus pulposus is avascular, the annulus fibrosus as well as the endplates are vascularised. IVD degeneration is often accompanied, on the one hand, by blood vessel ingrowth into the nucleus pulposus and, on the other hand, by diminished vascularisation of the endplates. Tissue engineering of IVD, therefore, has to address the differences in the vascularisation of IVD compartments. This chapter summarises current knowledge about the mechanisms of angiogenesis and its physiological and pathological role in IVD biology. Different strategies to control angiogenesis are discussed in the chapter with examples from bone tissue engineering, ophthalmological and oncological disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 |