6533b85efe1ef96bd12bfbcd
RESEARCH PRODUCT
Modulation of cytochrome P450 1A in sea bass liver by model substances and seawater extracts
Rudolf K. ZahnRenato BatelW. E. G. MüllerNevenka BihariŽEljko Jakšićsubject
SerranidaeEcologyHealth Toxicology and MutagenesisCytochrome P450Aquatic ScienceBiologybiology.organism_classificationBiochemistryFish livermedicinebiology.proteinDicentrarchusPhenobarbitalSeawaterSea bassSimple correlationmedicine.drugdescription
Abstract 1. 1. Immunochemical and catalytic assays for cytochrome P450 1A induction in liver of sea bass Dicentrarchus labrax treated with different model substances and organic seawater extracts have been performed. 2. 2. Ethoxyresorufin-O-deethylase (EROD) activities in fish liver were elevated by Arochlor 1254 (Aro), 3-methylcholanthrene (MC) and β-naphtoflavone (βNF). but not by phenobarbital (PB) treatment. 3. 3. Elevated levels of P450 1A protein followed by induction of EROD activity were detected only in βNF treated fish. 4. 4. Treatment of fish with organic seawater extracts revealed that there is no simple correlation between EROD activities and its catalyst P450 1A level. Seawater extracts are mixtures of chemicals that have the ability to suppress the levels of P450 1A and/or to inhibit EROD activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-01-01 | Aquatic Toxicology |