6533b85efe1ef96bd12bfde9
RESEARCH PRODUCT
New Strategy for the Stereoselective Synthesis of Fluorinated β-Amino Acids
Antonio NavarroAntonio Simon FuentesM. Carmen Ramírez De ArellanoEsther SalavertSantos FusteroBelén Pinasubject
Chiral auxiliaryHydrocarbons FluorinatedMolecular StructureReducing agentOrganic ChemistryMolecular ConformationStereoisomerismTautomerChemical synthesisEnaminechemistry.chemical_compoundchemistryDrug DesignCombinatorial Chemistry TechniquesOrganic chemistryStereoselectivityAmino AcidsChemoselectivityImideNuclear Magnetic Resonance Biomoleculardescription
Racemic and chiral nonracemic alpha-substituted and alpha-unsubstituted beta-fluoroalkyl beta-amino acid derivatives 6 and 9 have been synthesized in two steps starting from fluorinated imidoyl chlorides 1 and ester enolates. This approach is based on the chemical reduction of previously obtained gamma-fluorinated beta-enamino esters 4 by using ZnI(2)/NaBH(4) in a nonchelated aprotic medium (dry CH(2)Cl(2)) as the reducing agent. A metal-chelated six-membered model has been suggested to explain the stereochemical outcome of the reduction reaction. The process takes place with high yields and with moderate to good diastereoselectivity. The best results related to diastereoselective reduction of chiral beta-enamino esters 4 were provided by the use of (-)-8-phenylmenthol as a chiral auxiliary.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-05-29 | The Journal of Organic Chemistry |