6533b85efe1ef96bd12bfe35

RESEARCH PRODUCT

Probing the self-assembly and stability of oligohistidine based rod-like micelles by aggregation induced luminescence.

Mathias HaaseDaniel SpitzerPol BeseniusThomas BaschéHendrik FrischJens Voskuhl

subject

LuminescenceChemistryOrganic ChemistryPhosphate buffered salineAnalytical chemistryChemie02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesBiochemistryMicelle0104 chemical scienceschemistry.chemical_compoundAmphiphileBiophysicsLuminophoreHistidineParticle sizePhysical and Theoretical ChemistryAggregation-induced emissionParticle Size0210 nano-technologyLuminescenceMicelles

description

OA hybrid The synthesis and self-assembly of a new C2-symmetric oligohistidine amphiphile equipped with an aggregation induced emission luminophore is reported. We observe the formation of highly stable and ordered rod-like micelles in phosphate buffered saline, with a critical aggregation concentration below 200 nM. Aggregation induced emission of the luminophore confirms the high stability of the anisotropic assemblies in serum.

10.1039/c6ob00292ghttps://pubmed.ncbi.nlm.nih.gov/26972230