6533b85efe1ef96bd12bff75

RESEARCH PRODUCT

TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae.

Daniel GozalboM. Luisa Gil

subject

Hyphamedicine.medical_treatmentImmunologyHyphaeBiologyMicrobiologyModels BiologicalMicrobiologyMiceImmune systemCandida albicansmedicineAnimalsCandida albicansToll-like receptorCandidiasisbiology.organism_classificationCorpus albicansImmunity InnateToll-Like Receptor 2Toll-Like Receptor 4TLR2Infectious DiseasesCytokineImmunologyCytokinesCytokine secretion

description

Toll-like receptors (TLRs) function as sensors for infection that induce the activation of the immune responses. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans. Although both TLR2 and TLR4 have been implicated in the host interaction with C. albicans, their specific role during infection has not been unequivocally established, as conflicting results have been reported. In this review, we summarize and discuss our own and others' key findings about the specific role of TLR2 and TLR4 in murine resistance to candidiasis, and in triggering cytokine secretion by murine cells in response to C. albicans yeasts and hyphae.

yearjournalcountryeditionlanguage
2006-02-09Microbes and infection
10.1016/j.micinf.2006.03.014https://pubmed.ncbi.nlm.nih.gov/16973396