GRM2 tipa bakteriālo mikrokompartmentu daļiņu raksturojums

6533b85efe1ef96bd12c0190

RESEARCH PRODUCT

GRM2 tipa bakteriālo mikrokompartmentu daļiņu raksturojums

Eva Emīlija ČEsle

subject

Klebsiella pneumoniae bakteriālie mikrokompartmenti cryo-EM bakteriālais metabolisms Bioloģija biotehnoloģija

description

Bakteriālie mikrokompartmenti (BMC) ir baktēriju organellas, kas iepako enzīmus proteīnu čaulā. Šī darba mērķis bija analizēt iespējas GRM2 tipa BMC iepakot heterologus enzīmus, kā arī apskatīt rekombinanti producētu BMC čaulas īpašības. Šajā darbā Klebsiella pneumoniae GRM2 tipa BMC čaulā tika testēta trīs Zymomonas mobilis etanolģenēzes enzīmu iepakošana kā starpnieku izmantojot natīvo CutC holīna liāzes enzīmu un SpyTag/SpyCatcher adhezīnu sistēmu. Veikta arī bakteriālo mikrokompartmentu čaulas analīze ar cryo-EM. Darba ietvaros veikts konstruktu dizains, proteīnu ekspresija, attīrīšana, un analīze ar TEM un cryo-EM. Rezultāti liecina par zemu iepakošanas efektivitāti, ja kā mediators izmantots raksturenzīms holīna liāze. Ievērojami labākus rezultātus sniedza permutēta čaulas proteīna un SpyTag/SpyCatcher adhezīnu sistēmas izmantošana. Pēc cryo-EM analīzes aprēķinātas sešas BMC čaulas struktūras ar izšķirtspēju no 6,6 līdz22,2 Å, liecinot par BMC formu daudzveidību. Darbs izstrādāts Latvijas Biomedicīnas pētījumu un studiju centrā Dr. biol. Ginta Kalniņa vadībā.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/50718

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