6533b85efe1ef96bd12c06fb

RESEARCH PRODUCT

1 Hz rTMS enhances extrastriate cortex activity in migraine

Giuseppe GigliaAurelio PiazzaGaetano VitelloBrigida FierroSimona ScaliaRaffaella RicciFilippo Brighina

subject

AdultMaleVisual perceptiongenetic structuresAuraMigraine Disordersbehavioral disciplines and activitiesMagneticsExtrastriate cortexmedicineIllusory contoursHumansVisual CortexNeural Inhibitionmedicine.diseaseMigraine with auraKineticsmedicine.anatomical_structureVisual cortexnervous systemMigraineCerebral cortexVisual PerceptionFemaleNeurology (clinical)medicine.symptomPsychologyNeurosciencePhotic Stimulationpsychological phenomena and processes

description

We recently reported a paradoxical facilitatory effect of 1 Hz repetitive TMS (rTMS) on the primary visual cortex in migraine possibly due to the failure of inhibitory circuits, unable to be upregulated by low frequency rTMS. To investigate if inhibitory circuit dysfunction extends beyond striate cortex in migraine with aura, we studied the effects of 1 Hz rTMS over the right extrastriate cortex on perception of illusory contours in these patients. Low-frequency rTMS enhanced activity of extrastriate cortex in migraineurs, speeding up reaction times on illusory contour perception. This finding supports the view of a failure of inhibitory circuits also involving the extrastriate cortex in migraine with aura.

yearjournalcountryeditionlanguage
2003-01-01Neurology
https://doi.org/10.1212/01.wnl.0000094823.74175.92