6533b85efe1ef96bd12c0763

RESEARCH PRODUCT

Host immune response to Cryptosporidium parvum infection

Tesfaye Sisay TessemaFranz PetryVera Jakobi

subject

T-Lymphocytesanimal diseasesAIDS-Related Opportunistic InfectionsImmunologyAntibodies ProtozoanCryptosporidiosisAdaptive ImmunityBiologyNitric OxideImmunocompromised HostMiceImmune systemIntestinal mucosaImmunityparasitic diseasesAnimalsHumansIntestinal MucosaCryptosporidium parvumB-LymphocytesPhagocytesAIDS-Related Opportunistic InfectionsComplement System ProteinsDendritic CellsGeneral MedicineAcquired immune systembiology.organism_classificationVirologyImmunity InnateKiller Cells NaturalDisease Models AnimalInfectious DiseasesCryptosporidium parvumImmunologyCytokinesParasitologyImmunocompetenceImmunocompetenceCryptosporidium hominis

description

Species of the genus Cryptosporidium are protozoan parasites (Apicomplexa) that cause gastroenteritis in animals and humans. Of these Cryptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis. Whereas infection is self-limiting in the immunocompetent hosts, immunocompromised individuals develop a chronic, life-threatening disease. As specific therapeutic or preventive interventions are not yet available, better understanding of the immune response to the parasite is required. This minireview briefly summarizes the factors involved in the innate and acquired immune response in this pathogen-host interaction with an emphasis on more recent data from mouse models of infection.

yearjournalcountryeditionlanguage
2010-11-01Experimental Parasitology
https://doi.org/10.1016/j.exppara.2010.05.022