6533b85efe1ef96bd12c0796
RESEARCH PRODUCT
Nanozymes in Nanofibrous Mats with Haloperoxidase-like Activity To Combat Biofouling.
Juergen BriegerHéloïse Thérien-aubinWolfgang TremelKatharina LandfesterMelanie VielMinghan HuNadine WiesmannKarsten KorscheltMichael Kapplsubject
Materials scienceBiofoulingNanofibersNanotechnology02 engineering and technology010402 general chemistry01 natural sciencesBiofoulingHaloperoxidaseEscherichia coliGeneral Materials Sciencechemistry.chemical_classificationAqueous solutionNanotubesBiofilmMembranes ArtificialPolymerCerium021001 nanoscience & nanotechnologyElectrospinning0104 chemical scienceschemistryPeroxidasesNanofiberNanorod0210 nano-technologydescription
Electrospun polymer mats are widely used in tissue engineering, wearable electronics, and water purification. However, in many environments, the polymer nanofibers prepared by electrospinning suffer from biofouling during long-term usage, resulting in persistent infections and device damage. Herein, we describe the fabrication of polymer mats with CeO2–x nanorods that can prevent biofouling in an aqueous environment. The embedded CeO2–x nanorods are functional mimics of natural haloperoxidases that catalyze the oxidative bromination of Br– and H2O2 to HOBr. The generated HOBr, a natural signaling molecule, disrupted the bacterial quorum sensing, a critical step in biofilm formation. The polymer fibers provide porous structures with high water wettability, and the embedded cerium oxide nanozymes act as a catalyst that can efficiently trigger oxidative bromination, as shown by a haloperoxidase assay. Additionally, the embedded nanozymes enhance the mechanical property of polymer mats, as shown by a single-f...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 | ACS applied materialsinterfaces |