6533b85efe1ef96bd12c0871
RESEARCH PRODUCT
Self-assembly of janus dendrimers into uniform dendrimersomes and other complex architectures
Dalia H. LevineTimothy P. LodgeMichael L. KleinMark S. KaucherPawaret LeowanawatChristopher J. WilsonBrad M. RosenJarmo RopponenS. NummelinSami NummelinAnthony J. KimMonika J. SienkowskaEmad AqadDaniel A. HammerVirgil PercecFrank S. BatesRussell DevaneKari RissanenKevin P. DavisDaniela A. WilsonAndreea O. ArgintaruAndrew D. Hughessubject
Models MolecularDendrimersMaterials scienceSurface Propertiesta221Complex ArchitecturesNanotechnologyMolecular Dynamics SimulationSurface-Active AgentsBiomimetic MaterialsDendrimerAmphiphileJanusta218LiposomeDrug Carriersta214MultidisciplinaryAntibiotics Antineoplasticta114Molecular StructureVesicleCryoelectron MicroscopyWaterMembranes ArtificialNanostructuresJanus DendrimersSelf-AssemblyMembraneUniform DendrimersomesDoxorubicinPolymersomeSelf-assemblyHydrophobic and Hydrophilic Interactionsdescription
Janus Drug Delivery Vehicle Efficient drug delivery vehicles need to be produced in a limited size range and with uniform size distribution. The self-assembly of traditional small-molecule and polymeric amphiphiles has led to the production of micelles, liposomes, polymeric micelles, and polymersomes for use in drug delivery applications. Now, Percec et al. (p. 1009 ) describe the self-assembly of Janus-type (i.e., two-headed) dendrimers to produce monodisperse supramolecular constructs, termed “dendrimersomes,” and other complex architectures. The structures, which showed long-term stability as well as very narrow size distributions, were easily produced by the injection of an ethanolic solution of the dendrimer into water. The dendrimersomes could be loaded with the anticancer drug doxorubicin and exhibited controlled drug release with changing pH.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-21 | Science |