6533b85efe1ef96bd12c0878
RESEARCH PRODUCT
Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems.
Jozef Al-gousousPeter LangguthMaoqi FuIsam I. SalemYasuhiro Tsumesubject
medicine.medical_specialtyDrug LiberationIn vitro testChemistry PharmaceuticalPharmaceutical SciencePh dependentBiological Availability02 engineering and technologyPharmacologyIn Vitro Techniques030226 pharmacology & pharmacyDosage formBiopharmaceuticsExcipients03 medical and health sciences0302 clinical medicineDrug DiscoveryIntestine SmallmedicineIntensive care medicineGastric emptyingbusiness.industryHydrogen-Ion Concentration021001 nanoscience & nanotechnologyEnteric coatingBioavailabilityDrug LiberationSolubilityDrug deliveryMolecular MedicineTablets Enteric-Coated0210 nano-technologybusinessmedicine.drugdescription
First introduced in the second half of the 19th century, enteric coatings are commonly used to protect acid-labile drugs, reduce the risk of gastric side effects due to irritating drugs, or for local drug delivery to the lower gastrointestinal (GI) tract. The currently available enteric-coatings are based on pH-sensitive weakly acidic polymers. Despite the long history of their use, the causes behind their performance often being unpredictable have not been properly investigated with most of the attention being focused only on the gastric emptying. However, little attention has been given to the postgastric emptying disintegration and dissolution of these dosage forms. This lack of attention has contributed to the difficulty in predicting the in vivo behavior of these dosage forms and to cases of bioavailability problems with some enteric-coated products. Therefore, increased attention needs to be given to this issue.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-02-16 | Molecular pharmaceutics |