Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

6533b85efe1ef96bd12c08a0

RESEARCH PRODUCT

Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Susanne Schnell Dorothee Saur Tobias Bracht Ludger Tebartz Van Elst Dieter Ebert Nicolas Rüsch Klaus Lieb Volkmar Glauche Jürgen Hennig K. A. Il’yasov B. W. Kreher

subject

Adult Cingulate cortex Dorsum Adolescent Central nervous system Neuroscience (miscellaneous)610 Medicine & health 10056 Clinic for Clinical and Social Psychiatry Zurich West (former)Corpus callosum Gyrus Cinguli behavioral disciplines and activities Functional Laterality Corpus Callosum Young Adult 2738 Psychiatry and Mental Health Borderline Personality Disorder Neural Pathways mental disorders Image Processing Computer-Assisted medicine Humans 2741 Radiology Nuclear Medicine and Imaging Radiology Nuclear Medicine and imaging Borderline personality disorder Anterior cingulate cortex Brain Mapping Cognition Middle Aged medicine.disease Psychiatry and Mental health Diffusion Magnetic Resonance Imaging medicine.anatomical_structure nervous system 2801 Neuroscience (miscellaneous)Case-Control Studies Female Psychology Neuroscience Diffusion MRI

description

Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.

year	journal	country	edition	language
2008-11-12

10.5167/uzh-43616 https://doi.org/10.5167/uzh-43616