6533b85ffe1ef96bd12c10f7
RESEARCH PRODUCT
Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: involvement of μ-opioid receptors.
María José Sánchez-catalánLucía Martí-pratsLuis GraneroLucía HipólitoAna Polachesubject
MaleMicrodialysismedicine.medical_specialtyMicroinjectionsDopamineMicrodialysisNarcotic AntagonistsReceptors Opioid muNucleus accumbensNucleus AccumbensCellular and Molecular NeuroscienceNeurochemicalDopamineInternal medicineparasitic diseasesmedicineLimbic SystemAnimalsRats WistarChemistryVentral Tegmental AreaAntagonistCell BiologyIsoquinolinesConditioned place preferenceNaltrexoneRatsVentral tegmental areamedicine.anatomical_structureEndocrinologynervous systemOpioidConditioning OperantNeurosciencemedicine.drugdescription
Salsolinol (Sal), locally administered into the posterior VTA (pVTA) of rats, produces psychomotor responses and reinforcing effects, probably, through the activation of μ-opioid receptors (MORs). The neurochemical correlates of these phenomena are, however, practically unknown. In this paper, we explore the neurochemical events and the mechanisms involved in these behaviors. To do that, we test the ability of Sal, directly microinjected into the pVTA, to induce conditioned place preference (CPP) and to increase dopamine levels in the nucleus accumbens shell. Bilateral injections of 30 pmol of Sal induced a strong CPP (rats spent around 70% of the total test time), a result that could be explained by the fact that Sal microinjected into the pVTA increased DA levels in the ipsilateral accumbens up to 141% of baseline. The local pretreatment with β-FNA, an antagonist of MORs, prevented this increase, supporting our hypothesis on the involvement of MORs in the Sal-derived effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-03-01 | Neurochemistry international |