6533b85ffe1ef96bd12c1102
RESEARCH PRODUCT
Charge State of Silver Halide Colloids Determines the Antibacterial Activity in Amorphous Calcium Phosphate
Vizma NikolajevaDaina KalninaKarlis Agris GrossZivile Stankeviciutesubject
Materials scienceMinimum bactericidal concentrationSilver halidesilver iodidebone implantsMechanical EngineeringInorganic chemistrySilver iodidechemistry.chemical_elementHalidehydroxyapatiteCalciumcalcium phosphateschemistry.chemical_compoundchemistryMechanics of MaterialsantimicrobialGeneral Materials ScienceAmorphous calcium phosphateSolubilityAntibacterial activitydescription
Removal of bacteria is important not only at implantation, but after long-term implant/prosthesis use. This requires strategies that employ different approaches for combating bacteria. Halides have the potential of an additional mechanism, and together with silver may provide a more powerful antibacterial strategy. Silver iodide was synthesized as colloids with a positive and negative charge and incorporated into an amorphous calcium phosphate (ACP) to provide a possible greater antibacterial action. Colloids were characterized by FTIR spectroscopy and the charge measured by zeta potential. Phase analysis by X-ray diffraction patterns confirmed the formation of b-AgI nanoparticles. Minimum inhibitory concentrations (MIC) for preventing the growth ofStaphylococcus aureusandPseudomonas aeruginosawere lower for ACP containing negatively charged silver halides. Amorphous calcium phosphates with silver iodide exhibited good inhibition capacity. Solubility was determined by the increase in pH and the release of silver after 48 hours. The minimum bactericidal concentration (MBC) was also determined. This work has shown the effect of AgI charge in amorphous calcium phosphate for providing antibacterial action.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-11-01 |