6533b85ffe1ef96bd12c1200

RESEARCH PRODUCT

Induction of micronuclei in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol

Kristian JanssonVuokko Jansson

subject

PentachlorophenolMetaboliteHamsterToxicologycomplex mixturesChinese hamsterchemistry.chemical_compoundCricetulusCricetinaeGeneticsAnimalsDimethyl SulfoxideCells CulturedMicronuclei Chromosome-DefectiveCarcinogenMicronucleus TestsbiologyDimethyl sulfoxidebiology.organism_classificationMolecular biologyEffective dose (pharmacology)HydroquinonesPentachlorophenolchemistryBiochemistryMicronucleus testDNA Damage

description

Tetrachlorohydroquinone, a metabolite of the fungicide pentachlorophenol, induced significant dose-related increases in micronuclei in V79 Chinese hamster cells without exogenous metabolic activation. The lowest observed effective dose was 10 microM, where the relative survival was about 62%. At the highest dose tested, 20 microM, the relative survival was about 8% and the frequency of cells with micronuclei was about 6 times the solvent control frequency. The induction of micronuclei by tetrachlorohydroquinone was significantly inhibited by the hydroxyl radical scavenger dimethyl sulfoxide at 5% (v/v).

yearjournalcountryeditionlanguage
1992-06-01Mutation Research/Genetic Toxicology
https://doi.org/10.1016/0165-1218(92)90068-b