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RESEARCH PRODUCT
Novel Immune Features of the Systemic Inflammation Associated with Primary Hypercholesterolemia: Changes in Cytokine/Chemokine Profile, Increased Platelet and Leukocyte Activation.
Patrice MarquesPatrice MarquesHerminia González-navarroHerminia González-navarroElena DomingoJuan F. AscasoJuan F. AscasoJuan F. AscasoJosé T. RealJosé T. RealJosé T. RealAida ColladoMaria-jesus SanzMaria-jesus SanzMaria-jesus SanzLaura PiquerasLaura PiquerasSergio Martínez HervasEva Perellosubject
0301 basic medicineChemokinemedicine.medical_treatmentlcsh:Medicinechemokines030204 cardiovascular system & hematologySystemic inflammationArticleendothelial dysfunction03 medical and health sciences0302 clinical medicineleukocyte activationResposta immunitàriaprimary hypercholesterolemiaplatelet activationMedicinePlateletPlatelet activationEndothelial dysfunctionSistema cardiovascularsystemic inflammationbiologybusiness.industryMonocytelcsh:REndoteli vascularGeneral Medicinemedicine.diseasecytokines030104 developmental biologyCytokinemedicine.anatomical_structureImmunologybiology.proteinTumor necrosis factor alphamedicine.symptombusinessdescription
Primary hypercholesterolemia (PH) is associated with a low grade systemic inflammation that is likely the main driver of premature atherosclerosis. Accordingly, we characterized the immune cell behaviour in PH and its potential consequences. Whole blood from 22 PH patients and 21 age-matched controls was analysed by flow cytometry to determine the percentage of leukocyte immunophenotypes, activation, and platelet-leukocyte aggregates. Plasma markers were determined by Enzyme-Linked ImmunoSorbent Assay (ELISA). The adhesion of platelet-leukocyte aggregates to tumor necrosis factor-&alpha
year | journal | country | edition | language |
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2018-12-22 | Journal of clinical medicine |