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RESEARCH PRODUCT
Neuroprotective Potential of GDF11: Myth or Reality?
Luc RochetteGabriel Malkasubject
OpinionNeurogenesisNeovascularization PhysiologicNeuroprotectionCatalysislcsh:ChemistryInorganic ChemistryBlood plasmaAnimalsHumansRejuvenationrejuvenating factorsMedicinePhysical and Theoretical Chemistrylcsh:QH301-705.5Molecular BiologySpectroscopybusiness.industryOrganic ChemistryNeurogenesisBrainGeneral MedicineComputer Science ApplicationsGrowth Differentiation Factorslcsh:Biology (General)lcsh:QD1-999Bone Morphogenetic ProteinsGDF11GDF11neuroprotectionbusinessNeuroscienceBiomarkersdescription
In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-07-01 | International Journal of Molecular Sciences |