6533b85ffe1ef96bd12c199e
RESEARCH PRODUCT
A stereoselective synthesis of (+)-malyngolide via a ring-closing olefin metathesis
Miguel CardaSantiago RodriguezJ. Alberto MarcoEncarnación Castillosubject
chemistry.chemical_classificationAllylic rearrangementKetoneChemistryStereochemistryOrganic ChemistryErythruloseRing (chemistry)MetathesisBiochemistrychemistry.chemical_compoundRing-closing metathesisDrug DiscoveryStereoselectivityEnantiomerdescription
Abstract A very short and stereoselective synthesis of the non-natural enantiomer of malyngolide from l -erythrulose is described. Key features of the synthesis are the Felkin–Anh diastereoselective allylation of a polyoxygenated ketone and the allylation/metathesis/allylic oxidation protocol recently described by our group.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-07-01 | Tetrahedron Letters |