6533b85ffe1ef96bd12c1bae
RESEARCH PRODUCT
Antidepressant Effects of Exercise: A Role for the Adiponectin-PGC-1α-kynurenine Triad?
Fabian Sanchis-gomarAlejandro LuciaCarme Pérez Quilissubject
medicine.medical_specialtyPhysiologyClinical BiochemistrySaludchemistry.chemical_compoundTriad (sociology)Internal medicinemedicineAnimalsHumansExercise physiologyMuscle SkeletalEducación físicaExerciseKynurenineAdiponectinbusiness.industryKynurenine metabolismCell BiologyEjercicio físicoEndocrinologychemistryAntidepressantAdiponectinbusinessKynurenineTranscription Factorsdescription
It is well-recognized that exercise improves mental health, e.g., by decreasing depressive behaviors, improving hippocampal-dependent learning and neurogenesis, and increasing dendritic plasticity. Yet how exercise influences the brain at the molecular level is not clearly understood. Yau et al recently reported that the antidepressant effects of physical exercise are mainly mediated by adiponectin, an adipocyte-secreted hormone ('adipocytokine') with neuroprotective effects at the central nervous system level (Yau et al., 2014). 4.155 JCR (2015) Q1, 12/83 Physiology; Q2, 63/187 Cell biology UEM
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-26 | Journal of Cellular Physiology |