6533b85ffe1ef96bd12c1d4d

RESEARCH PRODUCT

Permeability of the bladder mucosa to thiotepa, adriamycin, and daunomycin in men and rabbits.

Nicolo' GebbiaMichele Pavone-macalusoF. BiondoS. BertoliniRizzo FpCaramia G

subject

NephrologyMalemedicine.medical_specialtyCancer chemotherapymedicine.drug_classUrologyAntibioticsUrinary BladderUrologyThioTEPAPharmacologyPermeabilityTransurethral surgeryInternal medicinemedicineAnimalsHumansQualitative differenceMucous MembraneChemistryBladder MucosaDaunorubicinDoxorubicinRabbitsThiotepamedicine.drug

description

The permeability of the bladder mucosa to thiotepa and to the anthraquinonic antibiotics, adriamycin and daunomycin, was investigated both in humans and in experimental animals. Instillations in rabbits were performed either in intact males or in animals with ligated ureters. Absorption of thiotepa was significantly higher than that of the antibiotics both in men and in rabbits. Furthermore, a qualitative difference was observed in rabbits in relation to time and with regard to fixation to vesical tissues. In man, absorption was highest after transurethral surgery. It was also increased in cases with extensive anaplastic tumours or in the presence of acute inflammatory reactions.

yearjournalcountryeditionlanguage
1976-04-21Urological research
10.1007/bf00256129https://pubmed.ncbi.nlm.nih.gov/821200