6533b85ffe1ef96bd12c1d98

RESEARCH PRODUCT

Dendritic cells in liver injury and fibrosis: shortcomings and promises.

Veronika Lukacs-kornekDetlef SchuppanDetlef Schuppan

subject

Liver CirrhosisLiver dendritic cellsPlasmacytoid dendritic cellBiologyCCL2MiceFMS-like tyrosine kinase 3 ligandFibrosismedicineAnimalsHumansAntigen-presenting cellLiver injuryHepatologyFlt3LDendritic Cellsmedicine.diseaseCD11c-DTRDisease Models Animalmedicine.anatomical_structurePhenotypeLiverImmunologyHepatic stellate cellDisease ProgressionBone marrowTolerance

description

SummaryThe phenotype and function of liver dendritic cells (LDCs) are poorly understood. This Snapshot summarizes our current knowledge on LDCs in the healthy and injured liver, and their role in fibrosis progression and reversal. It also draws attention to various pitfalls in the current experimental design and conclusions based on available data.

yearjournalcountryeditionlanguage
2013-11-01Journal of hepatology
10.1016/j.jhep.2013.05.033https://pubmed.ncbi.nlm.nih.gov/23727306