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RESEARCH PRODUCT
Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials
Vicente Zanon-morenoRicardo P. Casaroli-maranoRicardo P. Casaroli-maranoMaria D Pinazo-duranMaria D Pinazo-duranElena Rubio-velazquezMonica Del-rio-vellosilloJose Javier Garcia-medinaElisa Foulquie-morenosubject
0301 basic medicineretinaantioxidantPhysiologyEstrès oxidatiumedicine.medical_treatmentClinical BiochemistryVitrectomyReviewmedicine.disease_causeBioinformaticsBiochemistryAntioxidants03 medical and health sciences0302 clinical medicineDiabetic retinopathymedicineoxidative stressanimalhumanMolecular Biologybusiness.industryMechanism (biology)lcsh:RM1-950in vitroclinical trialCell BiologyDiabetic retinopathycellmedicine.diseasePathophysiologyIn vitroClinical trialdiabetic retinopathy030104 developmental biologylcsh:Therapeutics. PharmacologyOxidative stressRetinopatia diabètica030221 ophthalmology & optometryAnimal studiespatientbusinessOxidative stressdescription
Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-01 |