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RESEARCH PRODUCT
Classic Models for New Perspectives: Delving into Helminth–Microbiota–Immune System Interactions
Rafael ToledoAlba CortésCinzia Cantacessisubject
0301 basic medicineHelminthiasisHelminthiasisInterleukinBiologyGut floramedicine.diseasebiology.organism_classificationModels BiologicalHost-Parasite Interactions03 medical and health sciences030104 developmental biologyInfectious DiseasesImmune systemImmunological FactorsImmunityImmunologymedicineAnimalsHumansHelminthsParasitologyGut homeostasisdescription
Whilst a wealth of data indicate that infections by gastrointestinal helminths are accompanied by significant alterations in the composition of the vertebrate gut flora, little is known of the immune-molecular mechanisms that regulate host-parasite-microbiota interactions. 'Traditional' experimental models of gastrointestinal helminthiases, in which the role(s) of each of the components of this triad can be tested, provide an opportunity to advance research in this area. In this article, we propose the Echinostoma caproni-mouse system as a potentially useful tool for studies of the role of the host gut microbiota in preventing pathology and inducing parasite clearance via interleukin (IL)-25, an epithelial-derived alarmin with key roles in antihelminth immunity and maintenance of gut homeostasis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-08-01 | Trends in Parasitology |