6533b85ffe1ef96bd12c23df
RESEARCH PRODUCT
Proteins of Human Cytomegalovirus that Elicit Humoral Immunity
Lenore PereiraGerhard JahnDavid Navarrosubject
chemistry.chemical_classificationHuman cytomegalovirusmedicine.drug_classvirus diseasesBiologyMonoclonal antibodymedicine.diseaseFusion proteinVirologyImmune systemchemistryAntigenHumoral immunitymedicinebiology.proteinAntibodyGlycoproteindescription
Several of the cytomegalovirus (CMV) genes encoding glycoproteins, structural proteins, and infected-cell proteins that elicit an immune response in human infection have been mapped. Human sera and monoclonal antibodies react with these viral polypeptides made as native molecules in CMV-infected cells, as genetically engineered proteins, as truncated derivatives expressed in eukaryotic cells, and as bacterial fusion proteins from portions of the reading frames cloned into prokaryotic expression vectors. Synthetic oligopeptides from immunodominant regions of these molecules have also been used as antibody targets. Studies on proteins encoded by reading frames UL55, UL32, and UL44, on glycoprotein B, and on phosphoproteins pp150 and pp65 have been particularly fruitful. Recent developments employing these and other immunogenic CMV proteins as antigens for serodiagnosis of primary, recurrent, and past CMV infections are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 |