6533b85ffe1ef96bd12c23e6

RESEARCH PRODUCT

Oxygen Consumption Rate of Tumour Cells as a Function of their Proliferative Status

Wolfgang Mueller-klieserStefan Walenta

subject

CrystallographyChemistryGrowth phaseCell volumechemistry.chemical_elementOxygen

description

The oxygen consumption rate \(\left( \dot{Q}{{O}_{2}} \right)\) of EMT6/Ro-cells cultured as monolayers was investigated as a function of their proliferative status. The transition of these cells from the exponential to the plateau growth phase was associated with a continuous decrease in \(\dot{Q}{{O}_{2}}\) per single cell. This decrease can partially be attributed to a corresponding decline in cellular volume. In addition, the \(\dot{Q}{{O}_{2}}\) per cell volume was also reduced during the passage of the cells through the growth phase described. The results lead to the conclusion that a reduction in cellular volume and factors which are still unknown may contribute to the metabolic changes observed.

yearjournalcountryeditionlanguage
1987-01-01
https://doi.org/10.1007/978-1-4684-7433-6_47