6533b85ffe1ef96bd12c2674
RESEARCH PRODUCT
Anti-glomerular basement membrane antibody-mediated glomerulonephritis due to glue sniffing
M WeberRüdiger WaldherrD. E. Müller-wiefelH RuderK E BonzelA. M. Wingensubject
AdolescentSubstance-Related DisordersRenal functionKidneyurologic and male genital diseasesBasement MembraneImmunoglobulin GGlomerulonephritisSniffingAdhesivesHumansMedicineRapidly progressive glomerulonephritisAutoantibodiesBasement membranemedicine.diagnostic_testbiologybusiness.industryGlomerular basement membraneGlomerulonephritismedicine.diseasemedicine.anatomical_structureImmunoglobulin GPediatrics Perinatology and Child HealthImmunologybiology.proteinFemaleRenal biopsybusinessdescription
A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and deliberate sniffing of Pattex glue, a mixture of hydrocarbons which possibly may affect the structure of glomerular basement membrane. After treatment by repeated plasmapheresis and drug immunosuppression autoantibodies disappeared from serum but renal function was not influenced. Renal damage is a potential hazard for glue sniffing adolescents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-05-01 | European Journal of Pediatrics |