Gold(I) compounds with lansoprazole-type ligands

6533b85ffe1ef96bd12c271b

RESEARCH PRODUCT

Gold(I) compounds with lansoprazole-type ligands

Antonio Zucca Angela Casini Maria Agostina Cinellu Fabio Cocco E. F. J. Janssen E. Hemelt Benoît Bertrand Benoît Bertrand M. Serratice

subject

Pharmacology Stereochemistry Organic Chemistry Lansoprazole Pharmaceutical Science ANTIPROLIFERATIVE PROPERTIES SERIES Biochemistry TUMORS In vitro PROTON-PUMP INHIBITORS chemistry.chemical_compound chemistry CHEMISTRY TARGETS Drug Discovery medicine Molecular Medicine Imidazole SOLUTION BEHAVIOR COMPLEXES AGENTS Human cancer RESISTANCE medicine.drug

description

A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and nontumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.

year	journal	country	edition	language
2014-09-01	MedChemCommun

10.1039/c4md00241e https://doi.org/10.1039/c4md00241e

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