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RESEARCH PRODUCT
Peroxisomes and Hepatotoxicity
Norbert LatruffePatricia PassillyBrigitte JanninOlivier BardotMarie-claude ClémencetCorinne PacotMichel PetitPaul DeslexM. Cherkaoui MalkiFrançoise Cairasubject
chemistry.chemical_classificationCatabolismHematologyOxidative phosphorylationBiologyPeroxisomePathology and Forensic MedicineAmino acidEpoxide hydrolase activityMetabolic pathwayBiochemistrychemistryCatalaseGlyoxysomebiology.proteinAnatomydescription
Peroxisomes are ubiquitous organelles of eukaryotic cells and are present in significant amounts in hepatic liver cells. Peroxisomal enzymes contribute to several metabolic pathways including fatty acid, purine and amino acid catabolism or bile acid synthesis. The peroxisomal oxidative reactions produce hydrogen peroxide, mostly degraded by catalase which prevents oxidative stress. Moreover, peroxisomes are involved in arylderivative drug detoxification through its epoxide hydrolase activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 | Comparative Haematology International |