Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

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RESEARCH PRODUCT

Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

Yuangang Zu Nan Li Wei Wang Meng Luo Thomas Efferth

subject

Pharmaceutical Science Rosmarinus Analytical Chemistry law.invention chemistry.chemical_compound law Drug Discovery Food science Cytotoxicity Bicyclic Monoterpenes biology antibacterial activities 1 8-cineole Anti-Bacterial Agents Chemistry (miscellaneous)α-pinene Officinalis cytotoxicity Molecular Medicine Antibacterial activity Cell Survival Microbial Sensitivity Tests Rosmarinus officinalis L.Article lcsh:QD241-441 Bridged Bicyclo Compounds Inhibitory Concentration 50 lcsh:Organic chemistry Cell Line Tumor Botany Oils Volatile <em>Rosmarinus officinalis </em>L.; 1 8-cineole; α-pinene; β-pinene; antibacterial activities; cytotoxicity Humans Physical and Theoretical Chemistry IC50 Essential oil Eucalyptol Bacteria Plant Extracts Organic Chemistry Cyclohexanols biology.organism_classification Antineoplastic Agents Phytogenic Rosmarinus β-pinene Eucalyptol chemistry Monoterpenes Drug Screening Assays Antitumor Human cancer

description

In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.

year	journal	country	edition	language
2012-03-05	Molecules; Volume 17; Issue 3; Pages: 2704-2713

10.3390/molecules17032704 https://dx.doi.org/10.3390/molecules17032704