6533b860fe1ef96bd12c2fc7

RESEARCH PRODUCT

In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R

Aro Vonjy RamarosandratanaPaola PomaManuela LabbozzettaSergio RosselliMarco TutoneMaurizio SajevaMonica Notarbartolo

subject

lcsh:Medicinelcsh:RS1-441Pharmaceutical ScienceP-glycoprotein01 natural sciencesessential oilNF-κBFlow cytometrylcsh:Pharmacy and materia medicamultidrug resistanceDrug DiscoverymedicineChemosensitizing agentSettore BIO/15 - Biologia FarmaceuticaP-glycoproteincancer cellbiologymedicine.diagnostic_test010405 organic chemistryChemistrylcsh:RMyeloid leukemiamyeloid leukemia cellSettore CHIM/08 - Chimica FarmaceuticaMolecular biologyIn vitro0104 chemical sciencesMultiple drug resistance010404 medicinal & biomolecular chemistryApoptosisCell cultureSettore BIO/03 - Botanica Ambientale E ApplicataSettore BIO/14 - Farmacologiabiology.proteinMolecular Medicineinhibitors of apoptosis proteins

description

Euphorbia species have a large spectrum of traditional medicinal uses. We tested the biological activities of the essential oil (EO) of Euphorbia intisy Drake in an acquired multidrug resistance leukemia model to assess whether the EO obtained by hydrodistillation of stems was able to reverse the resistant phenotype. HL-60R cell lines are characterized by the overexpression of P-glycoprotein (P-gp), inhibitors of apoptosis proteins (IAPs) and constitutive expression of NF-κB. EO chemical composition was determined by GC/MS analysis

yearjournalcountryeditionlanguage
2021-01-31Pharmaceuticals
10.3390/ph14020111http://dx.doi.org/10.3390/ph14020111