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RESEARCH PRODUCT
Extracellular vesicles in multiple sclerosis as possible biomarkers: Dream or reality?
Fabiana GeraciEmanuele AliottaMaria Magdalena Barrecasubject
0301 basic medicinePathologymedicine.medical_specialtybusiness.industryMultiple sclerosisCentral nervous systemExtracellular vesicleDiseaseBiomarkermedicine.diseasePathogenesisTherapy efficacy03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structuremedicineBiomarker (medicine)Multiple sclerosiExtracellular vesiclebusinessPathological030217 neurology & neurosurgeryIntracellulardescription
Extracellular vesicles are recently described as specialized structures for intercellular communication. Their role in the central nervous system was diffusely studied in both physiological and pathological condition. In particular, an increased extracellular vesicle number was detected in several autoimmune diseases, including multiple sclerosis, a chronic autoimmune, inflammatory, demyelinating and neurodegenerative disease. This chapter summarizes the available information on the involvement of the extracellular vesicles in multiple sclerosis pathogenesis and their possible use as biomarker of therapy efficacy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |