6533b860fe1ef96bd12c3241
RESEARCH PRODUCT
Identification and determination of synthetic cannabinoids in herbal products by dry film attenuated total reflectance-infrared spectroscopy.
Salvador GarriguesVíctor De La Asunción-nadalMiguel De La GuardiaSergio Armentasubject
AnalyteChromatographyChemistryCannabinoidsPlant Extracts010401 analytical chemistryInfrared spectroscopy01 natural sciences0104 chemical sciencesAnalytical ChemistryMatrix (chemical analysis)Absorbance03 medical and health sciences0302 clinical medicineAttenuated total reflectionSynthetic cannabinoidsCalibrationSpectroscopy Fourier Transform InfraredmedicineCalibration030216 legal & forensic medicineFourier transform infrared spectroscopymedicine.drugdescription
A new procedure has been developed for the identification and quantitative determination of synthetic cannabinoids in illicit herbal preparations. The methodology is based on the use of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) measurement of sample extracts with 2-propanol drying 5µL of the extracts onto the ATR crystal. The qualitative identification was carried out on the 2-propanol extract after identification of the herbal matrix, followed by its subtraction and using a cut-off criterion of 75%. Quantitative determination was made by univariate calibration using the absorbance of the band located at 1520cm-1 of the spectrum. Four different cannabinoids, RCS-4, JWH-210, UR-144 and JWH-081 were used as test analytes and the ATR-FTIR method provided limits of quantification from 14 till 79mgL-1. Sized blank market samples were successfully identified and UR-144 quantified.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-05-01 | Talanta |