Antidiabētiskā medikamenta metformīna izraisītās funkcionālās izmaiņas cilvēka zarnu mikrobiomā

6533b860fe1ef96bd12c33b3

RESEARCH PRODUCT

Antidiabētiskā medikamenta metformīna izraisītās funkcionālās izmaiņas cilvēka zarnu mikrobiomā

Ilze Izabella Dindune

subject

metformīns zarnu mikrobioms metagenoms cukura diabēts Bioloģija

description

Metformīns ir antidiabētisks medikaments, kas samazina glikozes līmeni asinīs un nerada hipoglikēmiju, tomēr ~25% pacientu attīstās gastrointestinālas blaknes. Ir veikti pētījumi par metformīna terapijas ietekmi uz 2. tipa cukura diabēta pacientu zarnu mikrobiomu, tomēr pilnīga metformīna un zarnu mikrobioma mijiedarbības raksturojuma joprojām nav. Darba mērķis bija noskaidrot, kā metformīns ietekmē vesela cilvēka zarnu mikrobioma taksonomisko un funkcionālo profilu. Mikrobiālajai DNS no fēču paraugiem tika veikta metagenoma analīze ar lielapjoma paralēlo sekvenēšanu. Rezultāti parāda vairākas izmaiņu tendences gan taksonomisko grupu, gan signālceļu un gēnu saimju īpatsvarā jau 24 stundas pēc pirmās metformīna devas, novērotās tendences saglabāšanās arī pēc septiņu dienu ilgas metformīna lietošanas. Bakalaura darbs tika izstrādāts no 2016. gada maija līdz 2018. gada maijam Latvijas Biomedicīnas pētījumu un studiju centrā.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/38625

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